Meaning of active site in English:

active site


  • A region on an enzyme that binds to a protein or other substance during a reaction.

    ‘We propose that calcium ions set the machine in motion by initiating the contraction of the actin-myosin that they bind at active sites on the proteins.’
    • ‘The second step involves binding of phospholipid molecules in the active site of the adsorbed enzyme.’
    • ‘Extremes of pH or temperature irreversibly abolish enzyme activity, and so also do some substances that bind to the active sites of particular enzymes.’
    • ‘Buried carboxylic groups from the side chains of aspartic and glutamic acids are often found in the active sites of proteins.’
    • ‘According to simulations, such fast fluctuations could occur close to the active site of an enzyme.’