Meaning of antisense in English:


Pronunciation /ˈantɪsɛns/


  • Having a sequence of nucleotides complementary to (and hence capable of binding to) a coding (or sense) sequence, which may be either that of the strand of a DNA double helix which undergoes transcription, or that of a messenger RNA molecule.

    ‘The genotypes were confirmed by sequencing both sense and antisense strands using forward and reverse primers in separate reactions.’
    • ‘Both sense and antisense strands were sequenced from tumour samples; only forward strands were sequenced from corresponding normal tissue.’
    • ‘Broken arrows indicate starts of sense and antisense transcription.’
    • ‘The sense and antisense RNAs are complimentary and the strands will readily bind together to form a duplex.’
    • ‘Such mutants have been generated by chemical mutagenesis, gene disruption, and antisense gene silencing.’