Meaning of cryoglobulin in English:


Pronunciation /ˌkrʌɪə(ʊ)ˈɡlɒbjʊlɪn/


  • A protein which occurs in the blood in certain disorders. It can be precipitated out of solution below 10°C, causing obstruction in the fingers and toes.

    ‘RF, cryoglobulins and anti LKMI antibodies were the most frequently detected markers.’
    • ‘He also suggests potential autoimmune tests such as the rheumatoid factor for rheumatoid arthritis, cryoglobulins for cryoglobulinemia as well as the erythrocyte sedimentation rate for evidence of general inflammation.’
    • ‘The results of an autoantibody screen and testing for antineutrophil cytoplasmic antibodies were negative, complements were normal, and cryoglobulins were not detected.’
    • ‘A prospective study was then undertaken using serum from 100 consecutive patients with various monoclonal gammopathies and from 13 patients with polyclonal hypergammaglobulinemia and cryoglobulins.’
    • ‘Testing for human immunodeficiency virus and viral hepatitis was negative, as were tests for cryoglobulins.’