Meaning of frameshift mutation in English:

frameshift mutation

Pronunciation /ˈfreɪmʃɪft mjuˌteɪʃ(ə)n/


  • A mutation caused by the addition or deletion of a base pair or base pairs in the DNA of a gene resulting in the translation of the genetic code in an unnatural reading frame from the position of the mutation to the end of the gene.

    ‘We estimate that reversion of the lac mutation is about one-tenth as likely as a null frameshift mutation in a typical gene.’
    • ‘This frameshift mutation (deletion at positions 1151-1160) could be merely drifting to high frequency due to weak functional constraint.’
    • ‘In ORF 2 there is a deletion of 11 nucleotides that causes a frameshift mutation and a premature stop codon; an additional 1 bp insertion is located further downstream.’
    • ‘Thus, the base deletion that causes the frameshift mutation is present in the RNA population that was amplified as well as in the genomic DNA.’
    • ‘The 25-bp insertion causes a frameshift mutation and creates stop codons in all three reading frames.’