Meaning of invagination in English:


Pronunciation /ɪnˌvadʒɪˈneɪʃ(ə)n/


mass noun
  • 1Anatomy Biology
    The action or process of being turned inside out or folded back on itself to form a cavity or pouch.

    ‘This indicates a level of plasma membrane invagination comparable with mammalian skeletal muscle.’
    • ‘In the chick embryo, for example, the ectoderm initially expresses L-CAM; during neural plate invagination, however, L-CAM expression is replaced by that of N-cadherin.’
    • ‘Catheters with multiple side holes on several planes are less likely to cause invagination of airway mucosa into the catheter than those with single side or end holes.’
    • ‘Specifically, the ventral invagination and migration of mesodermal precursors in the embryo are severely impaired, as are head involution, dorsal closure, and the migration of gonadal precursors.’
    • ‘The initial conditions for the appearance of feathers also probably resides in processes common to all ammonites and include placode formation, invagination, and mesenchymal-epithelial interactions.’
    1. 1.1count noun A cavity or pouch formed by being turned inside out or folded back.
      ‘Intranuclear cytoplasmic invaginations, similar to that seen in non-neoplastic hepatocytes (or in metastatic melanoma) are also frequent.’
      • ‘These invaginations represent placental outgrowths and they extend towards the centre, enclosing the central hole into a triangular slit.’
      • ‘As is typical, many of the latter showed reactive changes, such as large, variably sized nuclei; intranuclear invaginations; and multinucleation.’
      • ‘The internodes have invaginations that are termed cupules.’
      • ‘There is a refracting secretion in the space of this invagination presumably protecting the photoreceptor cells.’


Mid 17th century from modern Latin invaginatio(n-), based on in-‘into’ + Latin vagina ‘sheath’.