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1A dose of a love potion, typically in tablet form; (now also) any of various pills intended to improve libido, sexual performance, or sexual satisfaction.
2slang (with the) the hallucinogenic drug 3,4-methylenedioxymethamphetamine, commonly known as Ecstasy.
Mid 17th century; earliest use found in William Strode (?1601–1645), poet and playwright.