Meaning of sickle cell anaemia in English:

sickle cell anaemia

Pronunciation /ˌsɪk(ə)l sɛl əˈniːmɪə/


(also sickle cell disease)
mass noun
  • A severe hereditary form of anaemia in which a mutated form of haemoglobin distorts the red blood cells into a crescent shape at low oxygen levels. It is commonest among those of African descent.

    ‘Infection can produce severe anaemia in people with sickle cell anaemia or other abnormalities of haemoglobin.’
    • ‘In sickle cell disease, the haemoglobin is abnormal and this causes a change in the shape of the red blood cells.’
    • ‘The blood condition sickle-cell anaemia is most common in people from Africa, the Caribbean, the eastern Mediterranean, the Middle East and Asia.’
    • ‘One out of four African Americans is born with alpha-thalassemia; therefore, at birth, one-fourth of African Americans with sickle cell disease have this ameliorating condition.’
    • ‘If an individual inherits the mutation in both genes they will have sickle cell disease.’
    • ‘His work focused on the antigen-antibody reaction and the structure of proteins and, in 1949, Pauling's team discovered the molecular basis of sickle cell anemia.’
    • ‘Already the genes for many diseases, from sickle cell anemia to heart disease, have been pinpointed, though genetic means of treating them are still in their infancy.’
    • ‘In the simplest cases, such as sickle-cell anemia, diseases can be linked to a single gene.’
    • ‘She talks about beauty basics, as well as major concerns affecting darker skins, such as the effects of sickle cell disease, scars and keloids.’
    • ‘An important breakthrough was the concept of molecular disease, introduced in the late 1940s with Linus Pauling's elucidation of the underlying basis of sickle cell anemia.’
    • ‘People with two copies of a form of a particular gene develop sickle cell anemia, but people with one copy of that form show high resistance to malaria.’
    • ‘My dad won the monthly National Science Prize when he designed a better cure for sickle cell anemia.’