Meaning of tacrine in English:


Pronunciation /ˈtakriːn/


mass nounMedicine
  • A synthetic drug used in Alzheimer's disease to inhibit the breakdown of acetylcholine by cholinesterase and thereby enhance neurological function.

    An acridine derivative; chemical formula: C₁₃H₁₅N₂Cl

    ‘The cholinesterase inhibitor tacrine is used rarely because of potential liver toxicity and the need for frequent laboratory monitoring.’
    • ‘These effects are comparable to those of the drug tacrine, which is prescribed for Alzheimer's disease.’
    • ‘The pharmacologic characteristics and side effects of tacrine make it a second-line agent.’
    • ‘Monitoring of serum transaminase levels is recommended with use of tacrine because of potential hepatotoxicity.’
    • ‘There have been no direct comparison studies to tacrine or donepezil.’


1960s from t(etra-) + acr(id)ine.