Meaning of tolbutamide in English:


Pronunciation /tɒlˈbjuːtəmʌɪd/


mass nounMedicine
  • A synthetic compound used to lower blood sugar levels in the treatment of diabetes.

    Alternative name: 1-butyl-3-tosylurea; chemical formula: C₁₂H₁₈N₂O₃S

    ‘For example, sulfonamides used for infection were noted to lower blood sugar and led to drugs such as tolbutamide for diabetes.’
    • ‘Based on studies of the distribution of first-generation sulfonylureas into breast milk, the AAP considers tolbutamide to be compatible with breast-feeding.’
    • ‘In some studies, karela extract has shown more hypoglycemic effects than the drug tolbutamide.’
    • ‘Examples of sulfonylureas include tolbutamide, chlorpropamide, glyburide and glipizide.’
    • ‘Alcohol-extracted charantin from Momordica charantia consists of mixed steroids and was found to be more potent than the oral hypoglycemic agent tolbutamide in an animal study.’


1950s from tol(uene) + but(yl)+ amide.