Definition of antagonize in English:


See synonyms for antagonize

Translate antagonize into Spanish

transitive verb

(also British antagonise)
[with object]
  • 1Cause (someone) to become hostile or angry.

    ‘he antagonized fellow architects by criticizing traditional values’
    • ‘she seemed reckless in the way she deliberately tried to antagonize her interviewers’
    arouse hostility in, alienate, set someone against someone else, estrange, disaffect
    View synonyms
  • 2Biochemistry
    (of a substance) act as an antagonist of (a substance or its action)

    • ‘two other drugs antagonized the antidepressant-like effect’



/anˈtaɡəˌnīz/ /ænˈtæɡəˌnaɪz/


Mid 17th century (in the sense ‘compete with’): from Greek antagōnizesthai, from ant- ‘against’ + agōnizesthai ‘struggle’ (see agonize).