1Cause (someone) to become hostile or angry.‘he antagonized fellow architects by criticizing traditional values’
arouse hostility in, alienate, set someone against someone else, estrange, disaffectView synonyms
- ‘she seemed reckless in the way she deliberately tried to antagonize her interviewers’
(of a substance) act as an antagonist of (a substance or its action)
- ‘two other drugs antagonized the antidepressant-like effect’
Mid 17th century (in the sense ‘compete with’): from Greek antagōnizesthai, from ant- ‘against’ + agōnizesthai ‘struggle’ (see agonize).