Definition of anticholinergic in English:


Pronunciation /ˌantēˌkōləˈnərjik/ /ˌæntiˌkoʊləˈnərdʒɪk/


  • (chiefly of a drug) inhibiting the physiological action of acetylcholine, especially as a neurotransmitter.

    ‘Main outcome measures: Numbers of elderly people with new prescriptions of highly anticholinergic antidepressants and less anticholinergic antidepressants.’
    • ‘He thought for a minute and added, ‘So, if we improve cognition by increasing acetylcholine, it makes sense that anticholinergic drugs can make dementia a lot worse.’’
    • ‘Antihistamine and anticholinergic drugs are relatively inexpensive.’
    • ‘Although statistically significant, the differences between anticholinergic drugs and placebo were small, apart from the increased rate of dry mouth in patients receiving active treatment.’
    • ‘Thyrotoxicosis, anticholinergic drug poisoning, and amphetamine or cocaine use can result in signs of increased sympathetic activity and altered mental status.’
    • ‘Older men with prostatic hypertrophy may benefit from alpha-blocker medications and should be watched for urinary retention if anticholinergic drugs are employed.’
    • ‘Amantadine, anticholinergic drugs, selegiline, and non-pharmacological treatments (such as physical therapy) provide symptomatic relief in mildly affected patients.’
    • ‘They dismiss conventional medical treatment with anticholinergic drugs as inconvenient, unpleasant, and temporary, and they say that patients usually stop using anticholinergic drugs because of a dry mouth.’
    • ‘Pharmacologic treatment of overactive bladder symptoms is based on the use of anticholinergic drugs that block the parasympathetic pathways and reduce detrusor muscle contraction.’
    • ‘This study demonstrates that moderate to severe dry mouth is common in patients treated with anticholinergic drugs.’
    • ‘Examples of anticholinergic drugs include atropine and ipratropium (Atrovent).’
    • ‘Until further research in primary care settings is performed, there is little evidence to guide family physicians in the choice of anticholinergic medications for urge incontinence.’
    • ‘The administration of antihypertensive and anticholinergic medications also impairs salivary functions and promotes xerostomia.’
    • ‘Nonetheless, the available anticholinergic drugs (atropine and ipratropium bromide) have limited effects, perhaps because of their nonselectivity.’
    • ‘Use of the anticholinergic drug atropine during tap-water iontophoresis sometimes is helpful, but extreme caution is necessary to avoid toxicity from atropine overdose.’
    • ‘In each of these cases, once the iatrogenic etiology of this syndrome was recognized, the patients' symptoms improved rapidly and dramatically with administration of anticholinergic medication.’
    • ‘This agent crosses the blood-brain barrier and thereby reverses both central and peripheral effects of the abused anticholinergic drug.’
    • ‘Dry mouth is the most common complaint with the oral anticholinergic drugs oxybutynin and tolterodine.’
    • ‘If these measures are not successful, an anticholinergic drug may control the pain.’
    • ‘Medical management consists of maintenance therapy with anticholinergic inhibitors such as pyridostigmine to relieve symptoms and steroids to treat the autoimmunity.’


  • An anticholinergic drug.

    ‘Both antihistamines and anticholinergics can have anticholinergic side effects, including dry mouth, urinary retention, blurred vision, and exacerbation of narrow-angle glaucoma.’
    • ‘Probably the most common medications used for the treatment of incontinence fall into the general category of anticholinergics or drugs designed to ‘relax’ the bladder.’
    • ‘These drugs are called anticholinergics and include oxybutynin, tolterodine, trospium chloride, and propiverine.’
    • ‘Dry mouth, which can be brought on by neuroleptics, antidepressants, and anticholinergics, may worsen the problem.’
    • ‘Agreement among guidelines is much greater regarding treatment - currently supporting the use of inhaled anticholinergics and antibiotics for initial treatment.’
    • ‘They recommend anticholinergics and antihistamines for the treatment of nausea associated with vertigo or motion sickness.’
    • ‘Short-term use of anticholinergics or antidiarrheal agents may be effective in combating incontinence associated with diarrhea.’
    • ‘Medications that may worsen confusion include anticholinergics, analgesics, cimetidine, central nervous system depressants, lidocaine, and other medications.’
    • ‘New medications, particularly anticholinergics and psychotropic medicines, should be the first suspects if there is a change in a patient's mental status.’
    • ‘Because even small amounts can be fatal, anticholinergics constitute the most dangerous class of abused drugs.’
    • ‘Thus, in 1914, anticholinergics by injection or inhalation were considered as first-line asthma therapies.’
    • ‘Moreover, anticholinergics do not appear to be effective for patients whose initial response to beta-agonists is impaired, and at this point, there is no clear consensus regarding their use.’
    • ‘Returning to our clinical scenario, we would recommend that our five-year-old patient with a moderate asthma exacerbation receive anticholinergics in addition to the [beta.sub.2] agonists and oral steroid therapy.’
    • ‘Acute care of an asthma exacerbation involves the use of inhaled [beta.sub.2] agonists delivered by a metered-dose inhaler with a spacer, or a nebulizer, supplemented by anticholinergics in more severe exacerbations.’
    • ‘Concomitant use of anticholinergics and beta 2 agonists may be beneficial to the older patient’
    • ‘Despite these uncertainties, anticholinergics are increasingly being used in both primary care and secondary care for the treatment of overactive bladder, and this has considerable implications for resources.’
    • ‘Anticholinergics have been used in an attempt to decrease gastric secretions and increase pH. As with the use of nasogastric tubes, anticholinergics do not decrease hospital stay or pain.’
    • ‘However, the effect of chronic treatment with anticholinergics on airway remodeling, responsiveness, and changes in lung function in patients with asthma is thus far unclear.’
    • ‘The most typical side effect of anticholinergics is dry mouth; other side effects include blurred vision, constipation, nausea, dizziness, and headache.’
    • ‘The medications most often used to help children with neurogenic bladder are called anticholinergics.’