Definition of colony-stimulating factor in English:

colony-stimulating factor

Pronunciation /ˈkälənē ˈstimyəˌlādiNG ˈfaktər/ /ˈkɑləni ˈstɪmjəˌleɪdɪŋ ˈfæktər/ /ˈfaktôr/ /ˈfæktɔr/


  • A substance secreted by bone marrow which promotes the growth and differentiation of stem cells into colonies of specific blood cells.

    ‘The maturation of white blood cells in the bone marrow and their release into the circulation are influenced by colony-stimulating factors, interleukins, tumor necrosis factor and complement components.’
    • ‘Growth factors are members of the cytokine family, which includes interleukins and colony-stimulating factors.’
    • ‘They are a large group of molecules and include the interferons, interleukins, and various colony-stimulating factors (CSFs).’
    • ‘Patients treated with granulocyte-macrophage colony-stimulating factor (GM-CSF) had significantly improved blood flow around blocked heart arteries compared with those who received a placebo.’
    • ‘Importantly, granulocyte-monocyte colony-stimulating factor has been demonstrated to improve gas exchange in a small series of patients with severe sepsis and respiratory dysfunction.’