Definition of CRISPR in English:


Pronunciation /ˈkrispər/ /ˈkrɪspər/


  • 1Biochemistry
    A segment of DNA containing short repetitions of base sequences, involved in the defense mechanisms of prokaryotic organisms to viruses.

    CRISPR sequences encode RNAs that can recognize specific target sequences in a genome, at which base pairs can be cut or added. They act in a complex with a specific protein that functions like a pair of molecular scissors, with which they are used as a tool in genetic engineering

    1. 1.1A genetic engineering tool that uses a CRISPR sequence of DNA and its associated protein to edit the base pairs of a gene.
      • ‘using the genome editing tool known as CRISPR, researchers were able to selectively silence two genes in human papillomavirus’


Early 21st century short for clustered regularly interspaced short palindromic repeat.