Definition of cryoglobulin in English:



  • Any of a group of abnormal plasma proteins, typically appearing in certain hematological, autoimmune, and infectious diseases, that become insoluble at temperatures below the core body temperature and may obstruct blood flow, especially in the skin.

    ‘RF, cryoglobulins and anti LKMI antibodies were the most frequently detected markers.’
    • ‘He also suggests potential autoimmune tests such as the rheumatoid factor for rheumatoid arthritis, cryoglobulins for cryoglobulinemia as well as the erythrocyte sedimentation rate for evidence of general inflammation.’
    • ‘The results of an autoantibody screen and testing for antineutrophil cytoplasmic antibodies were negative, complements were normal, and cryoglobulins were not detected.’
    • ‘A prospective study was then undertaken using serum from 100 consecutive patients with various monoclonal gammopathies and from 13 patients with polyclonal hypergammaglobulinemia and cryoglobulins.’
    • ‘Testing for human immunodeficiency virus and viral hepatitis was negative, as were tests for cryoglobulins.’



/ˌkrīəˈɡläbyələn/ /ˌkraɪəˈɡlɑbjələn/