Definition of downregulate in English:

downregulate

transitive verb

[with object]Physiology Biochemistry
  • Lower the rate or level of (a process such as gene expression, or sensitivity to a physiologically active substance) by downregulation.

Pronunciation

downregulate

/dounˈreɡyəˌlāt/ /daʊnˈrɛɡjəˌleɪt/