Definition of downregulation in English:

downregulation

noun

Physiology Biochemistry
  • 1The reduction at the cellular level of the magnitude or rate of a physiological response or a biochemical process, especially of the expression of a gene.

  • 2The reduction of the number or density of cell surface receptors for a physiologically active substance, causing a decrease in sensitivity in response to persistent exposure.

Pronunciation

downregulation

/ˌdounˌreɡyəˈlāSH(ə)n/ /ˌdaʊnˌrɛɡjəˈleɪʃ(ə)n/