Definition of downregulation in English:


Pronunciation /ˌdounˌreɡ(y)əˈlāSHən/ /ˌdaʊnˌrɛɡ(j)əˈleɪʃən/


Physiology Biochemistry
  • 1The reduction at the cellular level of the magnitude or rate of a physiological response or a biochemical process, especially of the expression of a gene.

  • 2The reduction of the number or density of cell surface receptors for a physiologically active substance, causing a decrease in sensitivity in response to persistent exposure.