Definition of imidazole in English:


Pronunciation /ˌiməˈdazōl/ /ˌɪməˈdæzoʊl/


  • A colorless crystalline compound with mildly basic properties, present as a substituent in the amino acid histidine.

    a heterocyclic compound; chemical formula: C₃H₄N₂

    ‘The quenching effect is attributed to the presence of proximal imidazole and pyrrole groups in their three-dimensional structures.’
    • ‘Conventional modeling of the amino acid side chains was used, that is, the zinc ligands aspartate, cysteinate, and histidine were modeled by acetate, methylthiolate, and imidazole, respectively.’
    • ‘In contrast, the lipid portion of the cuticular membrane, the cuticle proper and the matrix of the cuticular layer react with imidazole.’
    • ‘The trend in the photophysical properties found in the emission spectra parallels the changes in the photochemical properties with the electron-donating or electron-withdrawing power of the substituent on the imidazole ligand.’
    • ‘The thermal motion of imidazole axial ligands has also been investigated by electron paramagnetic and nuclear magnetic resonance spectra in proteins and synthetic models in homogeneous solution.’


Late 19th century from imide+ azo-+ -ole.