Definition of intrinsic factor in English:

intrinsic factor


  • A substance secreted by the stomach which enables the body to absorb vitamin B₁₂. It is a glycoprotein.

    ‘The vitamin is then bound by intrinsic factor, a protein secreted by parietal cells of the stomach, and carried to the ileum where it is absorbed.’
    • ‘Your stomach needs to secrete intrinsic factor in order to absorb B12, and if for some reason it doesn't, you will need to have regular vitamin B12 injections.’
    • ‘Without intrinsic factor, vitamin B - 12 can't be absorbed and leaves the body as waste.’
    • ‘In most cases, vitamin B12 deficiency happens because the stomach cannot produce enough of a substance called intrinsic factor, which is needed for vitamin B12 to be absorbed.’
    • ‘The detection of serum antibodies to intrinsic factor and an elevated serum gastrin level confirmed the diagnosis of pernicious anemia.’