Definition of it is all up with in English:

it is all up with

phrase

informal
  • It is the end or there is no hope for.

    • ‘Asked if he were willing to ‘concede that it is all up with the Republican Party now’ in the next election, he replied: ‘No, sir, I am not.’’
    • ‘‘Ah, he may think so,’ said the gaoler; ‘but it is all up with him, I can tell him.’’
    • ‘No, the first time I see him, it is all up with him, I can tell you.’
    • ‘‘I guess it is all up with me, boys,’ is what he moaned when death came.’
    • ‘If we do not run our belief about God into practical issues, it is all up with the vision God has given.’
    • ‘Let the circulation stop for one moment and the heart stops at the same time, and it is all up with the human machine!’
    • ‘He refers to California always as ‘God's country ’, and if you permit him to start his God's country line of talk, it is all up with intelligent conversation for the rest of the day.’
    • ‘The doctors say that it is all up with the old dear unless some food is got into him.’
    • ‘I believe that it is all up with the Union of the states; any compromise will come too late.’
    • ‘Man himself had been his greatest blunder; he had created a rival to himself; science makes men equal to God - it is all up with priests and gods when man becomes scientific!’