Definition of knockout mouse in English:

knockout mouse


  • A mouse whose DNA has been genetically engineered so that it does not express particular proteins.

    • ‘Postdoctoral fellow Deborah Burks, lead author of the Nature paper, decided to examine fertility in the knockout mice.’
    • ‘Liver regeneration is impaired in iNOS gene knockout mice.’
    • ‘More importantly, researchers can use knockout mice to develop better models of many inherited human diseases.’
    • ‘The phenotype of a knockout mouse provides important clues about the gene's normal role.’
    • ‘The knockout mice in the other cage were watched for 45 minutes (a little over 3 minutes are shown here) and no aggressive behavior was observed.’