Definition of methotrexate in English:


Pronunciation /ˌmeTHəˈtreksāt/ /ˌmɛθəˈtrɛkseɪt/


  • A synthetic compound that interferes with cell growth and is used to treat leukemia and other forms of cancer.

    Alternative name: 4-amino-10-methylfolic acid; chemical formula: C₂₀H₂₂N₈O₅

    ‘Cancer drugs used for primary bone cancer include methotrexate, doxorubicin, and cisplatin.’
    • ‘Treatment may include systemic steroids, intralesional steroid injection, antimalarials, or methotrexate.’
    • ‘Antimalarial drugs or immune response modifiers like methotrexate can reduce steroid dose and side effects.’
    • ‘Another combination is methotrexate plus cyclo-sporine and methotrexate.’
    • ‘The patient was treated with methotrexate and leukovorin calcium, and tumor lysis syndrome with acute renal failure occurred.’


1950s from meth- (denoting a substance containing methyl groups) + elements of unknown origin.