Definition of metyrapone in English:

metyrapone

Pronunciation /mɪˈtɪrəpəʊn/ /mɪˈtʌɪrəpəʊn/

noun

Pharmacology
  • A compound that inhibits the enzyme 17β-hydroxylase and prevents synthesis of glucocorticoids and mineralocorticoids by the adrenal gland, used chiefly for assessment of feedback control of the hypothalamic-pituitary axis in adrenal disease, and sometimes in the treatment of Cushing's syndrome and resistant oedema; 2-methyl-1,2-di-3-pyridyl-1-propanone, C ₅ H ₄ N·CO·C(CH ₃) ₂ ·C ₅ H ₄ N.

Origin

1960s; earliest use found in The Lancet. Probably from met- + -yr- + -a- connective + -p- + -one.