1A member of a North American Indian people formerly inhabiting north-western Florida.
Some of the Mikasuki are now members of the Seminole people of Florida, while others are members of the Miccosukee.
2The Muskogean language of the Mikasuki.
Of, relating, or belonging to the Mikasuki or their language.
Late 18th century; earliest use found in American State Papers, Indian Affairs. From the name of a former town in the Creek Confederacy, hence probably from Creek, but form and etymology unknown.