A native or inhabitant of Mytilene, the ancient city and modern capital of the Aegean island of Lesbos. Also more generally: a native or inhabitant of Lesbos.
The name of the modern city is frequently transliterated Mitilini. The island was formerly and is still sometimes known by the name of the city.
Of or relating to the city of Mytilene or the island of Lesbos.
Mid 16th century. From classical Latin Mytilēnaeus, also Mitylēnaeus (adjective and noun) Mytilenean or its etymon ancient Greek Μυτιληναῖος, also Μιτυληναῖος (adjective and noun) Mytilenean (from the name of Μυτιλήνη, the chief city of Lesbos) + -an.