Definition of neostigmine in English:



  • A synthetic compound that inhibits cholinesterase and is used to treat ileus, glaucoma, and myasthenia gravis.

    ‘At the end of procedures, the neuromuscular blockade was reversed, if necessary, with neostigmine, 0.03 mg/kg, and atropine, 0.015 mg/kg.’
    • ‘The study was terminated with the administration of atropine and neostigmine to reverse muscle paralysis.’
    • ‘The use of neostigmine to antagonise neuromuscular blockade may increase bowel motility and result in a higher rate of anastomotic leakage.’
    • ‘To reverse the muscle relaxation, neostigmine and atropine were used at the end of surgery.’
    • ‘This inhibition was observed in both the directly and indirectly stimulated contractions, and was not changed by addition of neostigmine, an acetylcholine esterase inhibitor.’



/ˌnēōˈstiɡmēn/ /ˌnioʊˈstɪɡmin/


1940s from neo-‘new’, on the pattern of physostigmine.