The words of a particular mantra or auspicious formula used in prayer and meditation, especially in Tibetan Buddhism, taking the form of an evocation of the bodhisattva Avalokiteśvara. Also as interjection Compare "om [interjection]".
Late 18th century. From Sanskrit oṃ maṇipadme hūṃ, evocation of the bodhisattva Avalokiteśvara from oṃ + maṇipadme, lit. ‘oh Maṇipadmā’, also interpreted as ‘oh jewel-lotus’ + hūṃ, sacred syllable used in an invocation.