Definition of procaine in English:



  • A synthetic compound derived from benzoic acid, used as a local anesthetic, especially in dentistry.

    ‘Dr. Persons says that chloroprocaine or procaine (Procaine, Novocain) should be safe in patients with true ‘amide’ allergy because they are esters.’
    • ‘In comparative studies, dry needling was found to be as effective as injecting an anesthetic solution such as procaine or lidocaine (Xylocaine).’
    • ‘History of an allergy to an ester anesthetic such as procaine is not a contraindication to the use of lidocaine, because they are chemically different, and cross-reaction is rare.’
    • ‘Since benzonatate is chemically related to anesthetic agents of the para-amino benzoic acid class, the drug should not be used in patients allergic to ester type agents (e.g., benzocaine, procaine, tetracaine).’
    • ‘An injectable solution of 1 percent lidocaine or 1 percent procaine is usually used.’
    • ‘Between the 21st July 1995 and the 31st November 1995 all the tablets purchased by the undercover police officers contain ephedrine procaine and ketamine, EPK.’
    • ‘Injectable local anaesthetics such as lidocaine and procaine (but not cocaine) are allowed only when medically justified, and only if injected into a joint or other affected area, not intravenously.’
    • ‘With 1 percent procaine and a fine sharp 25-gauge needle, raise skin wheals in the donor site - one for each graft and cut out a pinch of skin.’
    • ‘In the White House, Kennedy received ‘seven to eight injections of procaine in his back in the same sitting’ before news conferences and other events, Dr. Kelman said.’
    • ‘Ongoing staff education activities should include the topic of proper procaine and benzathine administration.’
    • ‘Intramuscular administration is possible but causes extreme pain if CaNa2EDTA is not mixed with procaine.’
    • ‘Normal saline solution is used as a placebo and 5% procaine hydrochloride is used as a pharmacologic spinal nerve block.’
    • ‘The local anesthetics procaine and tetracaine are known inhibitors of excitation-contraction coupling in frog skeletal muscle.’
    • ‘The onset of anesthesia with lidocaine is more rapid and the duration of action is longer than with procaine hydrochloride.’
    • ‘It is not surprising because of the stimulant properties that procaine is utilized as counterfeit stimulant in street-drug products although only having 10% of the potency of cocaine.’
    • ‘The second criterion was the occurrence of an IMS detection of procaine (an adulterant used to ‘cut’ cocaine).’
    • ‘That the White House physician, Dr. Janet Travell, gave him injections of procaine for his pain is old news.’
    • ‘If the therapeutic effects are satisfactory, at the local tender point, Radices Codonopsis Compositae or procaine solution can be injected, and epidural block therapy at sacral region can be applied.’



/ˈprōˌkān/ /ˈproʊˌkeɪn/


Early 20th century from pro- (denoting substitution) + -caine (from cocaine).