Definition of procoagulant in English:


Pronunciation /ˌprōkōˈaɡyələnt/ /ˌproʊkoʊˈæɡjələnt/


  • Relating to or denoting substances that promote the conversion in the blood of the inactive protein prothrombin to the clotting enzyme thrombin.

    ‘Protective mechanisms prevent thrombin and other procoagulant enzymes from forming in healthy intact blood vessels.’
    • ‘Thrombomodulin is an integral membrane glycoprotein that binds thrombin changing it from a procoagulant protein to an anticoagulant.’
    • ‘The cap acts as a protective barrier between circulating blood and the thrombogenic, procoagulant contents of the lesion.’
    • ‘Hemostasis involves the integration of many procoagulant proteins, natural anticoagulants, fibrinolytic proteins, and platelet surface glycoproteins.’
    • ‘In hemostasis, there is a balance between procoagulant factors and natural anticoagulant proteins.’


  • A procoagulant substance.

    ‘Taipan venom is overwhelmingly neurotoxic, including pre and post-synaptic neurotoxins, as well as powerful procoagulants and myolysins.’
    • ‘The exudate, procoagulants, and leukocytes form casts in the airways, resulting in poor gas exchange.’
    • ‘Chemotherapy acts by killing leukemic cells, which release procoagulants that can produce disseminated intravascular coagulation.’
    • ‘This phenomenon is attributed to platelet-aggregating factors and procoagulants from the tumor or its necrotic products.’
    • ‘When nitric oxide is deficient or used inadequately, endothelium becomes a procoagulant instead of an anticoagulant, and vasoactive molecules, cytokines, and growth factors are formed.’