Definition of tachyphylaxis in English:



  • Rapidly diminishing response to successive doses of a drug, rendering it less effective. The effect is common with drugs acting on the nervous system.

    ‘Trebling doses of histamine diphosphate were chosen instead of the usual doubling dose because of the half-life of lidocaine, the number of challenges, and the need to minimize possible tachyphylaxis of the histamine effect.’
    • ‘The efficacy of calcipotriene is comparable to mid-potency topical corticosteroids; however, it does not cause skin atrophy or tachyphylaxis.’
    • ‘This spirometric improvement was maintained throughout the 13-week period without any evidence of tachyphylaxis.’
    • ‘Giving methotrexate concurrently, however, suppressed tachyphylaxis, probably by preventing the production of human antichimeric antibodies.’
    • ‘Topical steroids should be applied no more than twice a day; more frequent use provides no advantage and may induce tachyphylaxis.’



/ˌtakəfəˈlaksəs/ /ˌtækəfəˈlæksəs/