Definition of transdifferentiation in English:


Pronunciation /tranzˌdifəˌrenSHēˈāSHən/ /trænzˌdɪfəˌrɛnʃiˈeɪʃən/


  • The rare natural transformation of cells other than stem cells into a different cell type.

    ‘Another possibility is to replace the missing function by causing transdifferentiation of existing cells.’
    • ‘Further scrutiny has also thrown cold water on many of the transdifferentiation claims for other types of adult stem cells.’
    • ‘Histology, immunohistochemistry, and ultrastructure were highly suggestive of transdifferentiation from cardiac muscle to adipose tissue.’
    • ‘A particularly interesting example of transdifferentiation, in which one cell type transdifferentiates into two different types in succession, is provided by jellyfish striated muscle.’
    • ‘We favor cytokine-and growth factor-dependent transdifferentiation of resident fibroblasts into myofibroblasts.’